Research Highlights

 

Goncalves KA, Silberstein L, Li S, Severe N, Hu MG, Yang H, Scadden DT, Hu GF.
Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells.
Cell. 2016 Aug 11;166(4):894-906. PMID:27518564.

 

Quail DF1, Bowman RL1, Akkari L2, Quick ML1, Schuhmacher AJ1, Huse JT3, Holland EC4, Sutton JC5, Joyce JA6.
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas.
Science. 2016 May 20;352(6288):aad3018. doi: 10.1126/science.aad3018.

 

Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT.
Proximity-based differential single cell analysis of the niche to identify stem/progenitor cell regulators.
Cell Stem Cell. 2016 Aug 9. PMID 27524439.

 

Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT.
Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia.
Cell. 2016 Sep 22;167(1):171-186.e15. doi: 10.1016/j.cell.2016.08.057. Epub 2016 Sep 15. PMID 2761501.

 

Wee B1,2, Pietras A3,4,5, Ozawa T3,4, Bazzoli E6, Podlaha O7,8, Antczak C9, Westermark B10, Nelander S10, Uhrbom L10, Forsberg-Nilsson K10, Djaballah H9, Michor F7,8, Holland EC3,4.
ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells.
Sci Rep. 2016 Jul 26;6:25956. doi: 10.1038/srep25956.

 

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