INTRATUMOR HETEROGENEITY DETERMINES BEST

TREATMENT MODALITIES IN BRAIN CANCER



Project Leader: Eric Holland, MD, PhD

Glioblastomas (GBMs) are the most common and most malignant primary brain tumors and can be divided into several molecular subgroups. All subtypes demonstrate high insensitivity to standard therapeutic approaches and, unfortunately, recurrence inevitably occurs. This project aims to better understand particular subtypes of GBMs and optimize intervention strategies. Particularly, the investigators hope to elucidate the combined effects of chemotherapy and radiation treatment on proneural-GBMs, to maximize radiation therapy responses in mesenchymal-GBMs and improve overall GBM treatment strategies independent of tumor subtype. Utilizing a multidisciplinary approach of basic biological and novel mathematical models, the investigators hope to further the understanding of therapeutic dynamics of treatment response to ultimately provide optimized and novel intervention strategies for GBM and improve the standard of care for patients.


 

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